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KMID : 0384119860060010077
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Korean Journal of Clinical Pathology
1986 Volume.6 No. 1 p.77 ~ p.83
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Biochemical Characteristlcs, Minimal Inhibitory Concentrations and Pyocin Types of Multiresistant Pseudomonas aeruginosa
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Abstract
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The infection rate of Pseudomonas aeruginosa has been increasing recently and the occurrence of multiple drug-resistant stains pose problems in the treatment and prevention against its infection. Authors studied the biochex lcal characteristics, minimal inhibitory concentration to several antibiotics and pyocin typing of multiresistant P. aeruginosa.
Twenty four strains which were resistant to all of amikacin, gentamicin, tobramycin, and carbenicillin by disc-agar-diffusion method were selected. The above studies were determined by the method of API 20NE, agar dilution method and Gillies and Govan method respectively. Fifteen strains of P. aeruginosa which were sensitive to all of the above 4 drugs were used as the control.
The results were as follows:
1. Biochemical profiles of. multisensitive strains were various, but 87% of mult
iresistant strains showed the same profile, API 20NE biotype No. 1354575.
2. Pyocin types of multisensitive strains were various, but the type of 87/ of
multiresistant strains was ( )
3. ´lost of multisensitive strains were also sensitive to the other antibiotics, such as, piperacillin, cefotaxime, cefoperazone, moxalactam and most of multiresistant strains were also resistant to them.
4. In vitro combination tests of gentamicin-carbenicillin, amikacin-cefoperazone, and amikacin-piperacillin, showed no significant difference of synergism between the antibiotic combinations summary the rn-ultiresistant strains showed almost identical biochemical
characteristics, pyocin types and antibiotic sensitivity patterns, suggesth,ng- hospital infection.
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